rpinon69, for home recordings it should be fine, though keep in mind that it's a mass produced budget consumer level interface for home audio/studio use mostly so it's quality /noise ratios / dynamic range will be not the same as pro level modules , simply because of quality of components used.
also Note that riffworks only records at 44100 Hz so as long as your interface supports 44100 NATIVELY you should be fine.
Here are some specs from Line6 :
For X3, the hardware always runs at 48000 Hz, 24 bit
means? when using riffworks, it will always downsample to 44100 through conversion, so there will be some quality loss, audible or not that only ears can decide.
For toneport users :
Sample Rate Converter:
TonePorts support 44.1 and 48 kHz sample rates natively. Some TonePorts also support 88 and 96 kHz sample rates by way of an "internal sample rate converter". This indicator lights up to show you when this converter is active, which can be any time your ASIO software is requesting a different sample rate than what your device “natively” supports. TonePort UX8 supports 44.1, 48, 88.2 and 96 kHz sample rates natively, meaning that these sample rates are not converted.
Menaing : You should use either 44.1 Khz or 48Khz on toneport for your Daws. that will not engage sample rate conversion.
for podxt , it's native sample rate is so low(39062.5 Hz) or 39.0625 Khz, 39062 Hz or 39063 Hz depending on where you round it off, that it always gets up-sampled, meaning it's trying you give out more resolution (by approximation) than it originally captured.
Frequency bandwidth is one of the big reasons why pro level modules are give native sample-rates up to 192 Khz . But i won't go into gory details of nyquist laws of sampling etc.

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